Chemonucleolysis Requires Chymopapain: Should We Accept Its Unavailability?

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The production of chymopapain and its availability in the United States and Europe has been discontinued by its manufacturer. This creates an untenable and unacceptable situation. Our patients are without chemonucleolysis (CNL), a proven treatment for disc related nerve root pain. FDA confirmed that Chymodiactin®, which is injected during the CNL procedure, was not discontinued for reasons of safety or effectiveness